| Pair Name | Oleanolic Acid, Sorafenib | ||
| Phytochemical Name | Oleanolic Acid (PubChem CID: 10494 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
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| Pair Name | Oleanolic Acid, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->Oxidative Stress | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP7 | hsa840 | |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 |
| Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 | |
| Result | OA represents a novel approach to increase the sensitivity of HCC cells to Sorafenib via oxidative stress. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells. Biochem Pharmacol. 2016 Oct 15;118:9-17. doi: 10.1016/j.bcp.2016.08.011. | Click |
